Saint Charles Vacation Rentals

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Make Saint Charles your next getaway

Saint Charles, MO vacation rentals

Explore Saint Charles house rentals, studios, and more

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House rentals

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Studios

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Saint Charles vacation rentals for every getaway

Popular
Internet Water view A/C
Lovely Couples Escape on Mississippi River!

Lovely Couples Escape on Mississippi River!

Studio in Saint Charles

$203 avg / night

5.0 (2)
Dreamy St Charles Retreat w/ Furnished Patio!

Dreamy St Charles Retreat w/ Furnished Patio!

House in Saint Charles

$416 avg / night

5.0 (6)
Saint Charles House Near Historic Downtown!

Saint Charles House Near Historic Downtown!

House in Saint Charles

$497 avg / night

5.0 (2)

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Listings nearby Saint Charles

Well-Appointed Townhome at STL Airport

Well-Appointed Townhome at STL Airport

Apartment in Saint Ann

$210 avg / night

‘Bross Brother's Cabin’ w/ Wraparound Porch!

‘Bross Brother's Cabin’ w/ Wraparound Porch!

House in Cottleville

$558 avg / night

4.88 (8)
A Private Escape Near St Louis

A Private Escape Near St Louis

House in Black Jack

$1,164 avg / night

5.0 (15)
Families Welcome! Spacious O'Fallon Home w/ Yard

Families Welcome! Spacious O'Fallon Home w/ Yard

House in O'Fallon

$372 avg / night

5.0 (6)

Vacation rentals near Saint Charles

Explore more vacation rental amenities in Saint Charles

Washer/dryer
Balcony
Snowbird-friendly

Recent Saint Charles vacation rental reviews

One of the most beautiful properties we've stayed at. Eagles , owls and many other birds. Lots of stars at night. Wonderful claw foot tub. Great retro vintage cabin. Can't wait to visit in summer. Andy
Andrew . | Feb 2026
Great location, close to Main Street. Within walking distance on a nice day (about a mile I’d say). Quiet neighborhood. Lovely house just as described. Clean and comfortable. We were there in the winter so did not use the outside patio area but it looked like it would be a wonderful option in warmer weather. Hosts were very quick to respond to any questions. They were warm and friendly with responses. Would not hesitate to stay with them again.
Christina . | Dec 2025
We had a wonderful weekend staying at this sweet cabin. We were in the area for a wedding nearby and found this space to stay in over a hotel and I am so glad we did! The owners were so wonderful to work with and we also enjoyed the extra baked goods they leave for their guests! We highly recommend this space for a peaceful weekend getaway!
Crissy . | Sep 2025
This house was perfect for my family. We came to St. Louis to visit family and as a family with three kids we need the space. My two boys are Autistic and don’t sleep well, so the basement room was perfect. They were able to hang out in the living area and then go to bed without disturbing my toddler upstairs. My mother stayed in the other master and even commented on how comfortable the beds were compared to most hotels. The tv has live tv guide, which was great for downtime. I appreciated the washer and dryer with available detergent with the kids. The location was perfect as well. Only 30 minutes from downtown activities and a short drive to downtown St. Charles with shops and restaurants. We would rent again!
Stasha . | Aug 2025
Saint Charles Frequently Asked Questions

Yes. 8 of our Saint Charles vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Saint Charles vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Saint Charles team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No worries, plans change. Read over our cancellation policy for more information. And if you currently have a Vacasa reservation for Saint Charles, log in to Trip Manager to see options available for your specific trip.

Book confidently. Stay comfortably.

Book confidently. Stay comfortably.
24/7 support
Easy check-in
Easy check-in
Professional cleaning
Professional cleaning

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