Seneca Vacation Rentals

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Make Seneca your next getaway

Explore our vacation rentals Seneca South Carolina. Our private accommodations include everything you need to have the perfect getaway, whether you're here for a family vacation, couples retreat, or making memories with friends.

Explore Seneca house rentals, apartments, and more

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House rentals

View 14 House rentals
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Apartments

View 9 Apartments

Explore more vacation rental amenities in Seneca

Pool | Lake view | Ocean view | Water view | Waterfront | A/C | Elevator | Washer/dryer | Balcony | Ping-pong table

Seneca vacation rentals for every getaway

Popular
Dog-friendly Hot tub Internet
Lake Keowee Home with Balcony & Boat Dock!
5 Bed | 5 Bath | Sleeps 14

Lake Keowee Home with Balcony & Boat Dock! - Seneca, SC

$1,593 avg / night
(excludes fees and taxes)
5.0 (25)
Lake Keowee Home:Sleeps 7,Lake Access,Coffee Bar
3 Bed | 2 Bath | Sleeps 7

Lake Keowee Home:Sleeps 7,Lake Access,Coffee Bar - Seneca, SC

$317 avg / night
(excludes fees and taxes)
1.0 (1)
7 Mi to Clemson Stadiums: Lake Keowee Getaway!
2 Bed | 2 Bath | Sleeps 6

7 Mi to Clemson Stadiums: Lake Keowee Getaway! - Seneca, SC

$393 avg / night
(excludes fees and taxes)
6 Mi to South Cove Boat Ramp! Lake Keowee Escape
2 Bed | 1 Bath | Sleeps 4

6 Mi to South Cove Boat Ramp! Lake Keowee Escape - Seneca, SC

$517 avg / night
(excludes fees and taxes)
Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!
2 Bed | 2 Bath | Sleeps 4

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch! - Seneca, SC

$359 avg / night
(excludes fees and taxes)
5.0 (1)

View 18 more homes

Recent Seneca vacation rental reviews

Awesome time, plenty of room for our party of 12. Kids game tables were in rough shape but usable. Perfect weather for our stay, water was swimable but murky. Kayaking and jumping off 2nd level dock was fun but be mindful of slivers, highly recommend water shoes. Stairs to the beach are not ideal for elderly or very young so plan accordingly. Will definitely rent this location again.
Ronald . | May 2026
It was amazing! My family loved the house-peaceful, quiet yet still close to many restaurants and grocery stores. We loved the basement-perfect for family game nights.
Cece . | Apr 2026
Enjoyed a wonderful Clemson football weekend. The house was perfect for our family’s needs. Super close and convenient to the stadium. From tailgate spot back to the house in under 15 mins after the game. The house was generously supplied with everything we could need. Beds were super comfy. Stephanie was an awesome host, and we look forward to staying again soon.
Amanda . | Nov 2025
Seneca Frequently Asked Questions

Yes, 9 of our Seneca homes allow dogs—so feel free to bring Fido along. (Just make sure to check individual home listings for any limits on the number and size of dogs they allow).

Browse dog-friendly homes >

Yes. 93 of our Seneca vacation rentals have internet access, so you can stay connected throughout your trip.

Browse homes with internet access >


Some of the most popular amenities in our Seneca vacation rentals include:

Our standard check-in time is 4:00 p.m., and the check-out time is 10:00 a.m. Some exceptions apply—after you book, you’ll find check-in and check-out details in the Vacasa guest app or your Trip Manager.

Absolutely. Our local Seneca team includes professional housekeepers who care for all our homes here. They’ll clean thoroughly and restock amenities, so everything is ready for your arrival—and all you have to do is settle in and relax.

Learn more about Vacasa Premium Clean >

No worries, plans change. Read over our cancellation policy for more information. And if you currently have a Vacasa reservation for Seneca, log in to Trip Manager to see options available for your specific trip.

Book confidently. Stay comfortably.

Book confidently. Stay comfortably.
24/7 support
Easy check-in
Easy check-in
Professional cleaning
Professional cleaning

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